Osteoarthritis (OA) is a condition which is observed in both humans and animals. It is a progressive degenerative disorder, typically affecting load bearing joints such as the hips, knees or elbows. Joint structure, function and integrity slowly deteriorate as the condition worsens.
Acute inflammation is the immediate response to an inflammatory agent (such as a pathogen or foreign material) or necrotic cells/tissue caused by cell injury and death. It undergoes many vascular changes in order to increase the amount of antibodies and leukocytes at the site of inflammation. The major contributing factors are:
Inflammation can be characterised by 5 main features (names in brackets are the Latin), these are:
Swelling (tumour) Heat (calor) Redness (rubor) Pain (dolor) Loss of function (functio laesa)
Inflammation is a protective response by the body towards cell injury. Cell injury may be due to; necrotic cells or tissue, the introduction of microbes [...]
NSAIDs are non-narcotic analgesics (An analgesic reduces or removes the sensation of pain), they are also anti-pyretic (fever) and anti-inflammatory. These effects are produced by the inhibition of the fatty acid cyclooxygenase (COX) which inhibits prostaglandin synthesis.
Because NSAIDs are non-narcotic they do not cause any largely noticeable effects on CNS (central nervous system) [...]
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